This journal was created as a forum for sharing information relating to Human Tumor Assays. It is a site for presenting research results, publishing editorials and reviews, and providing links to sites which pertain to the testing of fresh human tumor specimens to determine the probability that different forms of cancer treatment will be effective in individual patients and in different classes of neoplasms.

Human Tumor Assays are laboratory tests performed on fresh biopsy specimens of human neoplasms, which include the following procedures:

  1. 1.Isolating tumor cells from these specimens.

  2. 2.Exposing the tumor cells to drugs during short-term culture (3 - 7 days).

  3. 3.Assessing drug effects by measuring either cell proliferation or cell death.

The clinical application of these assays is based on the fact that drug effects in these assays correlates with and predicts the drug effects in the patients. The results are then used by clinical oncologists to select drugs to be used for the treatment of individual patients. This may be a "negative" selection (avoidance of drugs with a below-average probability of clinical benefit) and/or a "positive" selection (selection of drugs with an above-average probability of clinical benefit).

Edited by Larry Weisenthal, MD, Ph.D